Endocrine Abstracts

The transcriptional activator Bmal1, reaching acrophase in the morning and bathyphase in the evening, is the main regulator of circadian clock. A mutual interaction between circadian clock and glucocorticoids (GCs) has been described as well as their implication in muscle metabolism. The current in vitro study aims at investigating Bmal1 involvement in muscle catabolism induced by GCs circadian exposure. To this aim, mouse myocytes C2C12 were serum-shocked to synchron...

In vitro studies suggest that glucocorticoids (GC) long-term exposure downregulates SSTR2 but not SSTR5 expression in human and mouse ACTH-secreting tumor cells (AtT20), limiting the efficacy of octreotide (OCT), a somatostatin-receptor ligand with high affinity for SSTR2, in the treatment of Cushing’s disease (CD). In AtT20, dexamethasone treatment increased miR-375 expression, whose analysis revealed a seed-sequence for SSTR2, supporting the hypothesis that exc...

Introduction: Potent 11β-hydroxylase inhibitor osilodrostat provides cortisol level control in patients with Cushing’s syndrome (CS), as demonstrated by the LINC clinical development programme in Cushing’s disease (CD) patients.1 We report data from year 1 of the prospective observational LINC6 study (NCT05382156), evaluating long-term safety and efficacy of osilodrostat in CS patients during 3 years of routine clinical practice.<p class="abstext"...

Congenital adrenal hyperplasia (CAH) is a disorder due to mutations of genes coding for adrenal steroidogenesis enzymes, commonly caused by 21α-hydroxylase enzyme deficiency. Severe impairment of 21α-hydroxylase synthesis results in the classic form of CAH (c-CAH) characterized by cortisol and aldosterone deficiency (salt wasting form - SW), or partial enzyme deficiency characterized by cortisol deficiency (simple virilizing form - SV); mild impairment of 21α-hy...

Life-long glucocorticoid (GC) treatment is needed in patients with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, to replace GC deficiency and to control androgens excess. Multiple daily immediate-release-hydrocortisone (IR-HC), characterized by GC overexposure, peaks and troughs, is frequently associated with a suboptimal androgen control, due to ACTH overnight increase. Once daily dual-release-HC (DR-HC), approved for adrenal insufficiency and, despit...

Context: Prolactin (PRL) exerts a crucial role in the regulation of mammalian reproduction and in the promotion of lactation as response to the suckling reflex. Beyond this, it directly modulates gluco-insulinemic metabolism.ObjectiveTo dissect glucose metabolism during and after pregnancy in patients with chronic hyperprolactinemia (CTPE).MethodsThis longitudinal study included 52 reproductive aged women with CTPE due to pituitary adenomas (43 microadenomas, 9 macroadenomas),...

Purpose: The present study aimed at investigating the morphology and function of reproductive system in women with hyperprolactinemia (HPRL) receiving chronic treatment with cabergoline (CAB)Methods: Twenty-three women(aged 34.21&pm;10.09 yrs) with HPRL, including 17 with microprolactinoma, 3 with macroprolactinoma and 3 with iatrogenic HPRL, entered the study. All patients were well-controlled with CAB treatment (medium dose 0.46&pm;0.45 mg/week). In po...

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...

The potential independent role of growth hormone (GH) excess in sexual dysfunction of acromegalic male patients is poorly characterized. The aim of the current study was to evaluate the sexual function, in adult males with acromegaly, stratifying the cohort in “uncontrolled” and “controlled” disease. Data were retrieved from GONADIS, a national registry on gonadal status and reproductive and psycho-sexual function in patients affected by pituitary and adren...

The current study evaluated the impact of metabolic and hormonal alterations on sexual and psychological function in women with Polycystic Ovary Syndrome (PCOS). Fifty consecutive women aged 24.16&pm;5.97 years with a diagnosis of PCOS were recruited; metabolic and hormonal parameters were measured and questionnaires related to sexual function (Female Sexual Function Index-FSFI) and psychological traits (Middlesex Hospital Questionnaire-MHQ, Body Uneasiness Test A and B-BUT A ...